What is dbCAN meta server?

dbCAN meta server is a web server for automated Carbohydrate-active enzyme ANnotation, funded by the National Science Foundation (grant no. DBI-1652164). Similar resources on the web include CAZy, CAT, and Hotpep. dbCAN meta server is an updated version of the original dbCAN web server, while has the following new features (thanks to dbCAN users all over the world for suggestions):

  • dbCAN meta server allows submission of nucleotide sequences: prokaryotic genomic sequences (fna file) of draft genomes and metagenomes;
  • dbCAN meta server integrates three state-of-the-art tools/databases for automated CAZyme annotation:
    1. HMMER for annotated CAZyme domain boundaries according to the dbCAN CAZyme domain HMM database
    2. DIAMOND for fast blast hits in the CAZy database
    3. Hotpep for short conserved motifs in the PPR library
  • dbCAN meta server can identify transcription factors (TFs), transporters (TCs), and further CAZyme gene clusters (CGCs) using CGC-Finder if users submit faa+gff files or fna file
  • dbCAN meta server combines the results from the three tools and allows visualization as venn diagram and detailed results as graphs

dbCAN meta server will be updated once a year to use the most updated CAZy database, dbCAN HMM database and Hotpep peptide database


  • 8/15/2017: Tanner and HuangLe begin to work on dbCAN meta server
  • 7/1/2017: Yanbin is awarded the NSF CAREER grant for CAZyme bioinformatics research